Science
Numerous scientific studies and clinical trials have been carried out to determine Fernblock’s composition, action mechanism and efficacy:

Composition

Activity

Prevention of sunburn and phototoxic reactions
- Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin, MA Middelkamp-Hup, MA Pathak, C Parrado, D Goukassian, F Rius-Díaz, MC Mihm, TB Fitzpatrick, S González, J Am Acad Dermatol 2004 - Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin, MA Middelkamp-Hup, MA Pathak, C Parrado, T Garcia-Caballero, F Rius-Díaz, TB Fitzpatrick, S González, J Am Acad Dermatol 2004 - Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin, S González, MA Pathak, J Cuevas, VG Villarrubia, TB Fitzpatrick, Photodermatol Photoimmunol Photomed 1997 - Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by Polypodium leucotomos, S González, MA Pathak, Photodermatol Photoimmunol Photomed 1996
Anti-oxidant
- Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes, N Philips, J smith, T Keller, S González, J Dermatol Sci 2003 - Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by Polypodium leucotomos, S González, MA Pathak, Photodermatol Photoimmunol Photomed 1996
DNA protection
- Decrease of ultraviolet A light-induced “common deletion” in healthy volunteers after oral Polypodium leuctomos extract supplement in randomized clinical trial, A Villa, MH Viera, S Amini, R Huo, O Perez, P Ruiz, A Amador, G Elgart, B Berman, J Am Acad Dermatol 2010 - Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin, MA Middelkamp-Hup, MA Pathak, C Parrado, D Goukassian, F Rius-Díaz, MC Mihm, TB Fitzpatrick, S González, J Am Acad Dermatol 2004 - Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin, MA Middelkamp-Hup, MA Pathak, C Parrado, T Garcia-Caballero, F Rius-Díaz, TB Fitzpatrick, S González, J Am Acad Dermatol 2004
Immunological protection
- Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition, R Capote, JL Alonso-Lebrero, F García, A Brieva, JP Pivel, S Gonzalez, J Photochem Photobiol B:Biol 2006 - Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin, MA Middelkamp-Hup, MA Pathak, C Parrado, D Goukassian, F Rius-Díaz, MC Mihm, TB Fitzpatrick, S González, J Am Acad Dermatol 2004 - Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin, MA Middelkamp-Hup, MA Pathak, C Parrado, T Garcia-Caballero, F Rius-Díaz, TB Fitzpatrick, S González, J Am Acad Dermatol 2004
Anti-aging
- Decrease of ultraviolet A light-induced “common deletion” in healthy volunteers after oral Polypodium leuctomos extract supplement in randomized clinical trial, A Villa, MH Viera, S Amini, R Huo, O Perez, P Ruiz, A Amador, G Elgart, B Berman, J Am Acad Dermatol 2010 - Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens, and transforming growth factor-β by Polypodium leuctomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells, N Philips, J Conte, YJ Chen, P Natrajan, M Taw, T Keller, J Givant, M Tuason, L Dulaj, D Leonardi, S Gonzalez, Arch Dermatol Res 2009 - Photoprotective properties of a hydrophilic extract of the fern Polypodium leucotomos on human skin cells, JL Alonso-Lebrero, C Dominguez-Jiménez, R Tejedor, A Brieva, JP Pivel, J Photochem Photobiol B:Biol 2003 - Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes, N Philips, J smith, T Keller, S González, J Dermatol Sci 2003

Activity in Dermatological Pathologies

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